Viewpoint: necroptosis influences the type of liver cancer via changes of hepatic microenvironment

Cell death is a fundamental step in progression of various hepatic diseases. Necroptosis, an apoptosis alternate cell death, has been documented in various hepatic diseases. Just like apoptosis, necroptosis modulation could also halt disease progression and could be beneficial. Generally, necroptosis is thought to mediated by receptor-interacting serine/threonine-protein kinase-1 (RIP1), RIP3 and mixed lineage kinase domain-like pseudokinase (MLKL) (1).