Preferred location for the development of esophageal adenocarcinoma within a segment of intestinal metaplasia

Background Barrett’s metaplasia is the predominant precursor for the development of esophageal adenocarcinoma. This precancerous lesion has become the focus of various surveillance programs aimed at detecting earlier and therefore potentially curable lesions. However, sampling error by missing invasive cancer lesions is a common problem. This study aimed to identify preferred locations within a segment of Barrett’s mucosa for the development of esophageal adenocarcinoma.