Interactions between acetylcholinesterase and tetra-N-alkylammonium ions

Abstract A study of the mechanism of interaction of acetylcholinesterase with some simple tetra- N -alkyammonium ions has been made. Kinetic schemes have been proposed which are consistent with the experimental results observed in the enzyme-tetra- N -alkylammonium system in the presence of substrate and in the presence of an organophosphorus inhibitor.