Potential factors of endoscopic ultrasound-guided fine-needle aspiration (EUS-FNA) associated with percentage of classifying pathologic diagnosis for pancreatic diseases

Objective To investigate the clinical impact of endoscopic ultrasound-guided fine-needle aspiration(EUS-FNA) for the diagnosis of pancreatic diseases and potential factors associated with the percentage of classifying pathologic diagnosis in a prospective study.Methods Consecutive patients with indeterminate pancreatic diseases underwent EUS and EUS-FNA.The characteristics of patients and lesions,potential factors associated with the percentage of classifying pathologic diagnosis and complications were evaluated.Results Of 44 patients who underwent EUS,FNA was performed in 42 cases(95.5%),and the average maximum diameter of the lesions was(44.7±18.2) mm.Macroscopical tissue samples were obtained in 31 cases.Specimens sent for cytology or histopathology provided adequate material in 34 cases,accounting for an intention-to-diagnose yield of 77.3%(34/44).Patients with visible tissue samples had a higher percentage of classifying pathologic diagnosis(P=0.000).Errhysis at the point of puncyure occurred in 2 patients(4.8%,2/42),and were controlled by electric coagulation and hemostatic forceps.Conclusions EUS-FNA appeared to be a safe,feasible and effective procedure for the diagnosis of pancreatic diseases.The development of new techniques to obtain more samples for pathological analysis may well be valuable.