A New Approach for the Synthesis of Hyperbranched N-Glycan Core Structures from Locust Bean Gum

A novel protocol for the synthesis of general N-glycan core structures was established by means of Manβ(1→4)Man peracetate derived from a naturally abundant locust bean gum as a key starting material. Phenyl (2-O-benzyl-4,6-O-benzylidine-β-d-mannopyranosyl)-(1→4)-3,6-di-O-benzyl-2-azido-2-deoxy-1-thio-β-d-glucopyranoside facilitated the synthesis of key intermediates leading to hyperbranched N-glycan core structures.