Уровень липокалина в моче и острое повреждение почек у больных острым коронарным синдромом

The examination of 113 patients having acute coronary syndrome (ACS) (main group) and 11 patients with chronic stable angina (StA) (comparison group) was carried out. During the first three days of hospital stay, neutrophil gelatinase-associated lipocalin (NGAL) was detected in urine (u-NGAL), N terminal fragment of natriuretic peptide (NT-proBNP) and creatinine (sCr) in blood. It was discovered that u-NGAL level for ACS patients was higher than for the StA group. 11 ACS patients were diagnosed acute kidney injury (AKI) by sCr level and for them, u-NGAL value was higher than for non-AKI patients. Patients with various forms of ischemic heart disease were diagnosed chronic kidney disease (CKD) С1 С3. It is shown that u-NGAL level depends on CKD severity and maximizes at С3b. In the presence of ACS, correlation between u-NGAL and NT-proBNP content is discovered.