Interaction between Chlamydia pneumoniae seropositivity, inflammation and risk factors for atherosclerosis in patients with severe coronary stenosis

Objective. To investigate whether Chlamydia pneumoniae (Cpn) seropositivity in patients with suspected coronary artery disease (CAD) (n = 81) is associated with increases in markers of inflammation, the severity of coronary atherosclerosis, and traditional risk factors for cardiovascular events. Material and methods. The severity of coronary atherosclerosis was ranked by Gensini score. Inflammation and endothelial dysfunction were evaluated using white blood cell counts and levels of high‐sensitivity C‐reactive protein (hs‐CRP), ferritin, tumour necrosis factor‐α (TNF‐α), interleukins 1β and 6 (IL‐1β, IL‐6), soluble intercellular adhesion molecule‐1 (sICAM‐1), E‐selectin and oxidized LDL (oxLDL), and these were compared between Cpn‐seropositive and seronegative individuals. Results. IgA and IgG Cpn seropositivity were significantly associated with the presence of CAD (p = 0.005) and were independent predictive factors for the severity of coronary atherosclerosis (p = 0.005). Elevated levels of IL‐6 (p = 0...