Alpha‐I‐antitrypsin (Pi) phenotypes in Lyon, France: departure from Hardy‐Weinberg equilibrium

Philippe Arnaud,Janardan P. Pandey,H. Hugh Fudenberg,C. Chapuis-Cellier,P. Vlltoz,R. Creyssel

Alpha‐I‐antitrypsin (Pi) phenotypes in Lyon, France: departure from Hardy‐Weinberg equilibrium

2008

Philippe Arnaud
Janardan P. Pandey
H. Hugh Fudenberg
C. Chapuis-Cellier
P. Vlltoz
R. Creyssel

The validity of the Hardy-Weinberg equilibrium for Pi phenotypes was tested in a population of 1,653 randomly selected, healthy blood donors in Lyon, France. A significant departure from the equilibrium was found, with an excess of FF and SS homozygotes and a deficiency of FM heterozygotes.

Keywords:

Genetics
Phenotype
Pi
Endocrinology
Population
Alpha (ethology)
Internal medicine
Hardy–Weinberg principle
Biology
pi phenotypes

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