Synthetic Antimicrobial Peptide Tuning Permits Membrane Disruption and Interpeptide Synergy

Francisco R. Fields,Giorgia Manzo,Charlotte K. Hind,Jeshina Janardhanan,Ilona P. Foik,Phoebe Do Carmo Silva,Rashna D. Balsara,Melanie Clifford,Henry M. Vu,Jessica N. Ross,Veronica R Kalwajtys,Alejandro J Gonzalez,Tam T. T. Bui,Victoria A. Ploplis,Francis J. Castellino,Albert Siryaporn,Mayland Chang,J. Mark Sutton,A. James Mason,Shaun W. Lee

Synthetic Antimicrobial Peptide Tuning Permits Membrane Disruption and Interpeptide Synergy

2020

The ribosomally produced antimicrobial peptides of bacteria (bacteriocins) represent an unexplored source of membrane-active antibiotics. We designed a library of linear peptides from a circular ba...

Keywords:

Membrane
Antimicrobial peptides
Biochemistry
Antibiotics
Bacteria
Antimicrobial
Chemistry
Bacteriocin
Peptide

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