Intranuclear Distribution of Iron in Purkinje Cells in the Human Cerebellum

The distribution of iron ions in the cerebellum was studied in humans (n = 15) aged 20–89 years using a highly sensitive version of the Perls histochemical method. Elevated iron contents were seen in the white matter and Purkinje cells. In 10 cases out of 15, iron was seen in the nuclei of Purkinje cells, sometimes in the nucleolus.