Infulence of pyrasanone on the index of articular radioisotope (tc99m) uptake in rheumatoid arthritis

: Objective and instrumental appraisal of the therapeutic effect of a new inflammatory molecule (pyrasanone) via radio-isotope and clinical assessment is reported. A highly significant decrease in articular uptake of radiotechnetium was observed when pyrasanone was administered for a short period to 6 subjects with classic or definite rheumatoid arthritis. Clinical assessment after prolonged aministration in 40 patients with various rheumatic diseases with pathogenetice inflammation showed a marked anc clinically important anti-inflammatory (and hence analgesic) effct; tolerance was good and there were no side-effects.