One-pot synthesis of β-O-4 lignin models via the insertion of stable 2-diazo-1,3-dicarbonyls into O-H bonds

Lignin is a macromolecule that has received attention as a sustainable source of aromatic compounds. Due to the complex structure, the use of model substrates allows a better understanding of this macromolecule. However, few methods are described for the synthesis of these models. In this paper we describe a new route towards the synthesis of these oligomers by intermolecular O-H insertion reactions with simple and stable diazocarbonyls. This developed method showed shorter reaction times, high yields, as well as mild and green conditions.