Роль трансформирующего фактора роста бета в модификации внутриклеточных ангиогенных факторов при преждевременных родах

The results of the investigation of the content in the amniotic fluids of angiogenic and growth factors (NO, NO-synthase, arginase and vascular-endothelial growth factor (VEGF) and TGF β1) during physiological and urgent preterm delivery have been presented. The obtained data evidence that during the preterm delivery the increased myometrium cell activity is stipulated for disturbance of the processes, regulating in them Ca2+ level, in particular, at the expense of low NO content, which is one of the factors of increasing the contractile uterus activity. Decrease in generation of NO leads to violation of the reactions providing falling in cages a miometriya of level of ions of calcium which is one of factors of increase of constriction activity of a uterus. At this pathology, according to our data, falling of production of NO is caused by the high TFR-β1 level, inhibiting activity NO-synthase, carrying out generation of oxide of nitrogen from L-argin. The revealed disturbances of the content in the amniotic fluids of endogenous regulators of myometrium cell metabolism – angiogenic connections, allowed to determine the role of each of these bioactive components in the mechanism of birth activity beginning during preterm delivery.