α-Regioselective [3 + 2] Annulations with Morita-Baylis-Hillman Carbonates of Isatins and 2-Nitro-1,3-enynes.

An α-regioselective asymmetric [3 + 2] annulation reaction with Morita–Baylis–Hillman carbonates of isatins and (E)-2-nitro-1,3-enynes catalysed by cinchona-derived amines has been developed, providing spirooxindoles with contiguous chiral centres including adjacent quaternary ones in moderate to good yields with high enantioselectivity and excellent diastereoselectivity.