Hydroxylated sterols and the human fetal adrenal
1978
The conversion by isolated human fetal adrenal cells (24 wks gestation) of 25-OH-cholesterol (25-OH), 22S-OH-cholesterol (22S). 17,20-diOH-cholesterol(17,20) and 17-OH-pregnenolone(17-OH) into C21 and C19 steroids was studied.In additior the effects on the levels of free cholesterol (Chol) were determined. Substrates and products were estimated by capillary GC. Intracellular ATP was used as a viability criterion. Results: Production in μg/7×105 cells/2hrs DHEA=dehydroepiandrosterone; preg=pregnenolone The results suggest that these sterols not only act as precursors, but are able to stimulate steroid production by altering cellular metabolism.
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