OPTICAL RESOLUTION BY PREFERENTIAL CRYSTALLIZATION OF DL-METHIONINE HYDROCHLORIDE

DL-Methionine hydrochloride (DL-Met·HCl) was found to exist as a conglomerate, based on the infrared spectrum, solubility, and melting point. The optical resolution of DL-Met·HCl was successfully achieved by preferential crystallization into D-and L-Met·HCl. Treatment of the purified D- and L-Met·HCl with triethylamine gave D- and L-methionine of 100% optical purities. Chirality, 9;48–51, 1997. © 1997 Wiley-Liss, Inc.