Highly efficient oligosaccharide synthesis on water-soluble polymeric primers by recombinant glycosyltransferases immobilised on solid supports
2001
Recombinant β-1,4-galactosyltransferase (β1,4-GalT)
and α-2,6-sialyltransferase (α2,6-SiaT) immobilised covalently
with activated Sepharose beads were employed for the practical synthesis of
a trisaccharide derivative,
Neu5Acα(2→6)Galβ(1→4)GlcNAcβ-O-(CH2)
6-NH2, on a water-soluble primer having GlcNAc
residues through a α-chymotrypsin-sensitive linker.
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