Method of treating locally advanced unresectable oesophageal cancer
2011
FIELD: medicine. SUBSTANCE: invention refers to medicine, oncology, and may be used for treating locally advanced unresectable oesophageal cancer. Preliminary argon-plasma coagulation of a tumour is followed by high-power intraluminal brachytherapy on 1 st , 8 th and 15 th day of the therapeutic course at single basic dose 7 Gy combined with the intravenous introduction of taxane preparations and carboplatine. Further, the tumour is exposed to tele-radiation at single basic dose 1.8 Gy, 5 fractions/week, SOD 40-45 Gy, supported by the use of fluoropyrimidine derivatives in the following doses: oral administration of capecitabine 600 mg/m 2 in degree 0-1 dysphagia in days of radiation therapy, intravenous infusions of 5-fluorouracil 1000 mg/m 2 in degree 2-3 dysphagia every week. EFFECT: method provides optimising cytoreductive reaction of chemoradiation therapy components and more complete response of the tumour with relieved severe systemic and local reactions. 2 ex
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