157-LB: Association of Glycemic Ranges and Sleep Measures in Youth with T1D and Their Parents

Quality sleep is important for youth with type 1 diabetes (T1D) and their parents, yet disrupted sleep due to diabetes-related awakenings is common. Increased time-in-range (TIR, 70-180 mg/dL) and decreased time in hypoglycemia ( Youth age 3-17 years in an observational study had sleep and glycemic data collected. TIR and time in hypoglycemia throughout the day were compared with actigraphy data, including total sleep time (TST), sleep efficiency, wake after sleep onset (WASO), and number of awakenings. Linear mixed models were used to test associations between sleep variables with TIR and hypoglycemia. Twenty-six youth with T1D (mean age 10.7±4.0 yrs, median T1D duration 2.0 yrs [IQR 0.6, 4.8], HbA1c 7.2±1.4%, 50% female) and a parent were included. Significant associations were found between hypoglycemia and child WASO, awakenings, and TST. No associations were observed between TIR and sleep measures (Table 1). Time in hypoglycemia was associated with more nocturnal awakenings and WASO in youth with T1D. The association between hypoglycemia and child TST is unexpected and requires further evaluation. A larger sample size is needed to further evaluate correlations between glycemic outcomes and sleep measures. Tools to decrease hypoglycemia are important to improve sleep quality for youth with T1D. Disclosure A. J. Karami: None. L. Pyle: None. E. Jost: None. R. Wadwa: Consultant; Self; Tandem Diabetes Care, Research Support; Self; Dexcom, Inc., Eli Lilly and Company, Tandem Diabetes Care. L. J. Meltzer: None. E. C. Cobry: None. Funding National Institutes of Health (K12DK094712)