The Systematic Review and Implications of Organoid Technology
2021
Background: The induction of the formation of organoids derived from induced
pluripotent stem cells (iPSC) is a new technology that is being well studied and
aims to improve the clinical condition of patients with various diseases and even
patients undergoing certain types of procedures.
Methods: A systematic review, using the PRISMA protocol. The study period was
from 2010 to 2020 and the keywords included “Organoids”, “iPSC”, “Ethic” and
“Evidence-Based Medicine”, one at a time and then combined with the Boolean
operator “AND”.
Results: A total of 44 registrations were found. Of this total, 15 articles were
excluded because they have not approached organoids and stem cells objectively,
often attending to other phenomena or details that are not of interest to the
review.
Limitations: Discoveries about organoids and new methods to promote their
generation and growth are constantly being tested and developed around the
world, this implies a constant renewal of sources of information. The article was
based on current and highly respected sources in the scientific community.
Conclusion: Organoids are unquestionably a technology capable of changing
many concepts and guidelines in the medical environment. Faced with this
enormous capacity, it is necessary that studies are constantly made and that the
use of this new technology is widely discussed, since it addresses not only the
scientific sphere, but also the ethical sphere, the social sphere. Improving this
already existing technology so that it will increasingly mimic the human body is the
challenge that exists and needs to be addressed by many professionals in different
areas in harmony.
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