The results of genotyping in HPV-associated cervical infection

Aim: to evaluate the quantitative and qualitative composition of cervical human papillomavirus (HPV) infection in chronic cervicitis (CC). Materials and methods. The study included 102 patients with cervical HPV infection, mean age 33,9±1,1 years. The 1st group (main) consisted of patients with CC (n=39), 2nd group (comparison) - the patients with cervical intraepithelial neoplasia - CIN (n=50), group 3 (comparison) - patients with cervical cancer (n=13). Complex diag-cer nostics included liquid cytology, colposcopic, and histological examination of cervical biopsies and endocervical samples, advanced screening for high risk HPV DNA (16, 18, 31, 33, 35, 39, 45, 51, 52, 56, 58, 59 types) and low risk (6, 11 types) with viral load detection, screening for chlamydia and mycoplasmas DNA. Statistical analysis of data was performed using STATISTICA-6, functionality of MS Excel. Results. The prevalence of the same HPV type (56% and 64% respectively), two types (26 and 22%), three or more types (18 and 14%) in the 1st and 2nd group had no significant difference respectively. In the 1st group 45, 52 relative prevalence of HPV types was found in comparison with CIN, in which the predominance of 33 and 35 types of HPV (p 5 lg×105) was observed significantly more frequently (p 58, and 59 HPV types was shown in comparison with CIN, except for the viral load level.