ω-3 fatty acids prevent pressure overload-induced cardiac fibrosis through activation of cGMP/PKG signaling in cardiac fibroblasts

Background Omega-3 polyunsaturated fatty acids [ω-3 PUFAs, eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA)] from fish oil ameliorate cardiovascular diseases. However, little is known about the effects of ω-3 PUFAs on cardiac fibrosis, a major cause of diastolic dysfunction and heart failure. The current study assessed the effects of ω-3 PUFAs on cardiac fibrosis.