Biochemistry of Blood Plasma and Some Parameters of Antioxidant Status in Rats with Polyhypovitaminosis of Varying Severity

In rats with profound vitamin defi ciency, blood plasma level of triglycerides signifi cantly decreased by 1.6 times, potassium ions by 5%, uric acid by 23%, ALT and AST by1.4 times, while the levels of glucose increased by 32%, iron by 31%, urea by 58%, and alkaline phosphatase by19%. Plasma level of phosphorus tended to decrease and ionized calcium concentration tended to increase. Severe defi ciency of all vitamins is accompanied by pronounced accumulation of MDA in the plasma and liver together with simultaneous increase in the level of coenzyme Q 10 by 4.6 times and decrease in vitamin C content by 21.4% in the rat liver compared to the control. It was found that severe combined defi ciency of vitamins for 4 weeks produced considerable multidirectional alterations in diagnostically important metabolic parameters in rat plasma.