Pulmonary vascular resistance predicts mortality in patients with pulmonary hypertension associated with interstitial lung disease: results from the COMPERA registry.

Pulmonary hypertension (PH) is a common complication of many chronic lung diseases, especially chronic obstructive pulmonary disease (COPD) and interstitial lung disease (ILD) [1]. In these conditions, the development of PH is associated with an aggravation of symptoms and an increase in mortality risk. In most patients with chronic lung disease, the haemodynamic severity of PH is mild to moderate, while some patients develop severe PH, which is presently defined by a mean pulmonary arterial pressure (mPAP) ≥35 mmHg or mPAP ≥25 mmHg in the presence of a cardiac index <2.0 l·min·m–2 [2]. These haemodynamic criteria were introduced per expert consensus but were not based on solid data. Footnotes This manuscript has recently been accepted for publication in the European Respiratory Journal . It is published here in its accepted form prior to copyediting and typesetting by our production team. After these production processes are complete and the authors have approved the resulting proofs, the article will move to the latest issue of the ERJ online. Please open or download the PDF to view this article. Conflict of interest: Karen M. Olsson. Conflict of interest: Marius M. Hoeper. Conflict of interest: Christine Pausch. Conflict of interest: Ekkehard Grunig. Conflict of interest: Doerte Huscher. Conflict of interest: David Pittrow. Conflict of interest: Stephan Rosenkranz. Conflict of interest: Henning Gall.