HSP60 and bronchial asthma

Bronchial asthma (asthma) is a chronic and complex airway inflammatory disease characterized by airway hyper-responsiveness.Current asthma therapies are limited to specific disease manifestations,highlighting the importance of developing treatments with broader treatment applications.CD4-T lymphocytes,which produce a characteristic repertoire of cytokines,play a critical role in the development of airway inflammation,mucus production and airway hyper-responsiveness in asthma.Recently,it has been demonstrated that heat shock protein 60 (HSP60) could mediate CD4-T lymphocyte differentiation,suggesting that HSP60 can be targeted in the development of novel anti asthma medications,especially for the treatment of severe disease or refractory patients.This review summarizes the current knowledge regarding the relationship between HSP60 and asthma. Key words: Heat shock protein 60 ;  CD4-T lymphocytes ;  Bronchial asthma