New Products from the Reactions of Artemisinin with Ammonia and Amines

Reaction of artemisinin (1) with ammonia, methylamine, dimethylamine, and allylamine afforded five unexpected products 2−6, in addition to the previously reported compounds 7−12. The identities of the new compounds were established from their spectral data, by chemical derivatization and by comparison with published reports. The stereochemistries of compounds 5 and 6 were confirmed by single-crystal X-ray analysis.