Effect of losartan on acute renal failure induced by severe ethylene glycol poisoning in rats

The effect of an angiotensin receptor II antagonist (losartan) on the model acute renal failure (ARF) induced by severe ethylene glycol poisoning at 2/3 LD50 has been studied in rats. It is established that losartan administration (20 mg/kg for 72 h) produces a significant (4-fold) increase in the animal death rate, which is associated with ARF transition to a decompensation stage. Pronounced changes in the qualitative and quantitative composition of diurnal diuresis, more than 8-fold increase in the creatinine level, and 18-fold increase in the blood urea have been observed. Thus, the administration of losartan to ethylene glycol poisoned rats causes more pronounced degeneration of proximal tubule epithelium and destruction of glomeruli. It is concluded that the use of losartan for the treatment of ARF is inexpedient.