A green route for the synthesis of pyrrolo[2,3-d]pyrimidine derivatives catalyzed by β-cyclodextrin

Herein, we present the synthesis of pyrrolo[2,3-d]pyrimidine derivatives, which are important heterocyclic scaffolds in the field of synthetic and pharmaceutical research, via biomimetic catalysis. This strategy involves the use of β-cyclodextrin as a reusable promoter and water as an eco-friendly reaction medium. The merits of this protocol are high atom economy, mild reaction conditions, good yields of desired products in short reaction times, and reusable reaction medium.