Effect of sedatin, a synthetic dermorphin analog, on cell division in the corneal and lingual epithelia of rats

Sedatin, an analog of the opioid peptide dermorphin, which is a mixed μ- and δ-receptor agonist, had no effect on DNA synthesis and mitotic activity in the corneal or lingual epithelium of rats in a single dose 10 μg/kg, but stimulated cell division in both epithelia in a single dose of 100 μg/kg and in the 10 μg/kg dose administered either once daily over a 21-day period or just once after a single injection of the opiate receptor antagonist naloxone.