Effects of adenosine A 2A receptor antagonists on cocaine-induced locomotion and cocaine seeking

Rationale and objectives Adenosine signaling through adenosine A2A receptors (A2ARs) is known to influence cocaine-induced behaviors. These studies sought to elucidate how two A2AR antagonists distinguished by their antagonist effects at presynaptic and postsynaptic A2AR influence cocaine-induced locomotion and cocaine seeking.