Incidence and Characteristics of Non-Hodgkin Lymphomas in a Multicenter Case File of Patients With Hepatitis C Virus-Related Symptomatic Mixed Cryoglobulinemias

fied as nonaggressive in 31 cases (53%), aggressive in 20 (34%), and mucosa-associated lymphoid tissue lymphomas in 6 (10%); 2 cases were unclassifiable. The median timefromthediagnosisofCStotheclinicalonsetofNHL was6.26years(range,0.81-24years).Theclinicalcourse and response to chemotherapy in the patients with CS who had NHL were similar to those usually described in patients with NHL without CS; the course of the CS only marginally benefited from chemotherapy. Conclusions: The overall risk of NHL in patients with CS is about 35 times higher than in the general population(12timeshigherifnonaggressivelymphomasareexcluded). The presence of CS did not significantly affect the treatment of newly diagnosed lymphomas. Arch Intern Med. 2005;165:101-105