Comment on Kramer et al. Glucagon Response to Oral Glucose Challenge in Type 1 Diabetes: Lack of Impact of Euglycemia. Diabetes Care 2014;37:1076–1082

We have read the study by Kramer et al. (1) concerning glucagon response to oral glucose challenge in type 1 diabetes with great interest. Although a paradoxical increase in glucagon in response to oral glucose may be one of the significant causes of hyperglycemia in patients with type 1 diabetes, its results should be carefully interpreted …