1,2-Asymmetric Induction in Dianionic Allylation Reactions of Amino Acid Derivatives - Synthesis of Functionally Useful, Enantiopure Aspartates and Constrained Scaffolds.

Abstract Dianions derived from N-Cbz aspartic acid esters undergo highly stereoselective anti allylation reactions at the unsubstituted carbon. The roles of additives, of the cation and of the electrophile were studied. Synthetic applications and potential utility in peptidomimetic design are also described.