АТРОФИЯ ГОЛОВНОГО И СПИННОГО МОЗГА У ПАЦИЕНТОВ С РЕМИТТИРУЮЩИМ РАССЕЯННЫМ СКЛЕРОЗОМ: 3-ЛЕТНЕЕ ДИНАМИЧЕСКОЕ ИССЛЕДОВАНИЕ

Nowadays  neurodegeneration in multiple  sclerosis  is closely associated  with irreversible  disability progression. However, the involvement sequence  of different regions in atrophy is still unclear. The aim of our study was to determine the relationship  between  brain and spine atrophy and neurological  disability in relapsing-remitting multiple sclerosis (RRMS)  patients. 45 RRMS patients  underwent  brain and spine MRI with voxel based morphometry  and neurological examination with EDSS and were compared to 20 healthy controls. As a result we determined  a distinct patterns of atrophy distribution  in MS patients  and the sequence  of involvement of different central nervous system regions. A strong correlation between disability progression  rate and gray matter atrophy rate was detected.