Research development of biological profile of male breast cancer

Male breast cancer (MBC) is a rare and special male malignant tumor whose morbidity is much lower than that of female breast cancer (FBC) due to the different physiological factors. There have been multiple well-meaning attempts to show that, after adjusting for stage and age, the prognosis of MBC is similar to that of FBC, but there are vast differences in the expression of hormone receptors, HER-2, Ki-67 and BCL2. With developments in molecular biology and the transcriptosomic landscape of breast malignancy, there will be an increase in our knowledge of the molecular differences between breast cancer in females and males. For MBC patients, these differences may be of great importance for the prognosis and systemic therapy. Summing up the relevant literatures in China and abroad in recent years, this paper provides an overview of the molecular biology research progress of MBC, in order to strengthen the understanding and attention of clinicians and patients for MBC. Key words: Breast neoplasms, male; Neoplasm staging; Tumor markers, biological