Determinants of homocysteine concentrations in mother and neonatal girl pairs.

ofolate. the methyl donor for methylation of Hcy to methionine. is the most frequent genetic cause of elevated Hcy concentration [3]. An identified C to T substitution at 677 in the MTHFR gene [C677T/MTHFR (A222V)] relatively increases Hcy concentration in subjects with the TT genotype. In this present study. we aim to evaluate the effects of nutritional and genetic factors on plasma Hcy concentration among neonatal girls and their mothers in Japan. Prior to this study ， ethical approval was obtained from a special committee at Nagasaki University (project registration number 100614189). Bl ood samples were obtained the day after delivery from 200 healthy mothers with uncomplicated pregnancies at Nagasaki University Hospital and four clinics/hospital s