Numerical assessment of device-related thrombus formation triggered by the contact system
2019
Thrombosis is a major concern in blood-coated medical devices. In the present study, pro-coagulant
reactions including the contact activation system are coupled with a fluid solver as well as a
recently proposed thrombus formation model. The resulting biochemical/fluid model is applied to a
backward facing step configuration, a flow configuration that frequently appears in medical
devices. Simulations show that the contact system induces a large concentration of thrombin is the
recirculation zone without the need of an a priori knowledge of the thrombus location. Platelets are
then chemically activated and generate a thrombus whose both position and growth rate are in good
agreement with the experimental data available.
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