Bisphenol A deteriorates egg quality through HDAC7 suppression

// Bin Liu 1 , Shasha Zhou 2 , Chenmin Yang 3 , Ping Chen 4 , Pingping Chen 1 , Di Xi 1 , Hong Zhu 1 and Yuping Gao 1 1 Department of Assisted Reproduction, Xinhua Hospital, School of Medicine, Shanghai Jiaotong University, Shanghai 200092, People’s Republic of China 2 Department of Endocrinology, Shanghai Children’s Hospital, Shanghai Jiaotong University, Shanghai 200040, People’s Republic of China 3 Department of Obstetrics and Gynecology, Ruijin Hospital, School of Medicine, Shanghai Jiaotong University, Shanghai 200023, People’s Republic of China 4 Institutes of Biomedical Sciences of Shanghai Medical School, Fudan University, Shanghai 200032, People’s Republic of China Correspondence to: Yuping Gao, email: gaoyuping@xinhuamed.com.cn Keywords: bisphenol A, egg, HDAC7 Received: May 04, 2017     Accepted: August 26, 2017     Published: September 28, 2017 ABSTRACT Bisphenol A (BPA), a synthetic substance of endocrine disrupter, widely distributes in environment and can affect the health of ovarian follicles, thereby impacting the fertilization ability and pregnancy rate. However, the underlying mechanisms regarding how BPA disrupts the egg quality have not been fully revealed. In this study, we determine that BPA treated female mice display the decreasing HDAC7 expression in ovary and eggs compared to control. Moreover, the global levels of H3K9 and H4K16 acetylation abnormally increase after BPA treatment and recover partially upon HDAC7 compensation. Collectively, our study reveals that BPA deteriorates egg quality through HDAC7 suppression.