Nucleolin directly mediates Epstein-Barr virus immune evasion through binding to G-quadruplexes of EBNA1 mRNA.

María José Lista,Rodrigo Prado Martins,Olivier Billant,Marie-Astrid Contesse,Sarah Findakly,Pierre Pochard,Chrysoula Daskalogianni,Claire Beauvineau,Corinne Guetta,Christophe Jamin,Marie-Paule Teulade-Fichou,Robin Fåhraeus,Cécile Voisset,Marc Blondel

Nucleolin directly mediates Epstein-Barr virus immune evasion through binding to G-quadruplexes of EBNA1 mRNA.

2017

María José Lista
Rodrigo Prado Martins
Olivier Billant
Marie-Astrid Contesse
Sarah Findakly
Pierre Pochard
Chrysoula Daskalogianni
Claire Beauvineau
Corinne Guetta
Christophe Jamin
Marie-Paule Teulade-Fichou
Robin Fåhraeus
Cécile Voisset
Marc Blondel

Cells infected with Epstein-Barr virus (EBV) express the virus-encoded EBNA1, which is essential for viral genome maintenance but also highly antigenic. Here the authors implicate nucleolin as a host factor that mediates the repression of EBNA1-derived antigenic peptides…

Keywords:

Psychological repression
Molecular biology
Host factor
Antigen
Epstein–Barr virus
Nucleolin
Virus
Antigenic variation
Virology
Biology
RNA-binding protein

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