An alternative synthesis of Vandetanib (Caprelsa™) via a microwave accelerated Dimroth rearrangement
2017
Vandetanib is an orally available tyrosine kinase inhibitor used in the treatment of cancer. The current synthesis proceeds via an unstable 4-chloroquinazoline, using harsh reagents, in addition to requiring sequential protection and deprotection steps. In the present work, use of the Dimroth rearrangement in the key quinazoline forming step enabled the synthesis of Vandetanib in nine steps (compared to the previously reported 12–14).
Keywords:
- Correction
- Source
- Cite
- Save
- Machine Reading By IdeaReader
15
References
11
Citations
NaN
KQI