Oligopeptide or its modified compound/derivant and application thereof

The present invention provides an oligopeptide capable of affecting platelet function or modification thereof RGT / derivative, and a modified oligopeptide or RGT / derivatives in the prevention and / or treatment of arterial thrombotic diseases and / or integrated with other outside-β3 pixel signal transduction mediated diseases related application guide. RGT oligopeptides or modifications thereof, the derivative treated platelets /, outward in integrin signal transduction related functions were decreased, and the inside-out signal transduction substantially unaffected; prevent irreversible platelet aggregation formed, reducing platelet activity, prevent thrombosis stable while still retaining portions and adhesion and platelet aggregation capacity, which can inhibit thrombus formation and to maintain the basic part of the normal hemostatic function.