Traditional Chinese Medicine for Food Allergy and Eczema

Objective To summarize the recent evidence of traditional Chinese medicine (TCM) for food allergy and eczema. Data Sources Published literature from PubMed database and abstract conference presentations. Study Selections Studies relevant to TCM for food allergy and eczema were included. Results TCM is the main component of complementary and alternative medicine in the US. Food Allergy Herbal Formula 2 (FAHF-2) (derived from classical formula Wu Mei Wan) prevented systemic anaphylaxis in murine models and showed safety and preliminary immunomodulatory effects on T cells and basophils. Phase II trial of combined TCM with OIT and Omalizumab for multiple food allergy is ongoing. Retrospective practice-based evidence study showed that comprehensive TCM therapy effectively prevented frequent and severe food anaphylaxis triggered by skin contact or protein inhalation. The traditional Japanese herbal medicine Kakkonto suppressed allergic diarrhea and decreased mast cells in intestinal mucosa in a murine model. Active compounds from TCM showed potent inhibition of IgE, mast cell activation and pro-inflammatory cytokines/signaling pathway (TNF-α, IL-8, NF-kB) suggesting value for both IgE and non-IgE mediated food allergy. Triple TCM Therapy including ingestion, bath, and cream markedly improved skin lesion, itching, sleep loss in patients with corticosteroid dependent, recalcitrant, or topical steroid withdrawal. Xiao Fang San and Japanese, Korean formulas showed effectiveness in eczema. Acupuncture reduced wheal size, skin itching, basophil activation in atopic dermatitis. TCM are generally safe. Conclusion TCM has potential as safe and effective therapy for food allergy and eczema. Further research is needed for botanical drug development and for further define the mechanisms of actions.