POLÍTICA DE PROIBIÇÃO DA DIPIRONA

Dipyrone is one of the most widely used analgesics / antipyretics in Brazil. However, due to the suspicion of causing agranulocytosis, this drug has been withdrawn in more than 30 countries, including: United States, Japan, Australia, and much of the European Union. The goal of this essay was bringing up some issues related to dipyrone’s forbiddance. Thus, a commented literature review was carried out about the possible adverse reactions and toxicity associated with the use of dipyrone as well as the controversial issue related to its prohibition. Although dipyrone has historically been associated with the occurrence of agranulocytosis, several studies have shown that when compared to other analgesics / antipyretics available, this drug has a better risk-benefit ratio, in addition to having toxicity at acceptable levels. On the other hand, its widespread, good margin of safety and low cost are important justifications for its use and commercialization as a non-prescription medicine. This essay also discusses ethical, sociological and political aspects that go beyond the prohibition of dipyrone.