Triazolone derivatives pyridinyl and pyridinyl condensed triazolone

A compound of Formula 1, Formula ** ** a tautomer thereof or a pharmaceutically acceptable salt the compound or tautomer, wherein: R1 is selected from hydrogen, halo, -CN, C1-4 alkyl, C1-4 haloalkyl and -OR14; each of R2 and R3 is independently selected from hydrogen, halo, -CN, R6, and R7, or R2 and R3 together with the carbon atoms to which they are attached form a benzene ring or a pyridine ring in wherein the benzene ring is optionally substituted with one to four substituents independently selected from halo, -CN, R6 and R7, and the pyridine ring is optionally substituted with one to three substituents independently selected from halo, -CN, R6 and R7; R4 has the formula wherein indicates a point of attachment; L is selected from -O-, -CH2O- and -N (R4e) -; R4a is selected from -CH2R5 and ethenyl optionally substituted with one to three substituents independently selected from halo, cyano and R7; and (a) R4c is hydrogen, R 4e is selected from hydrogen and C1-4alkyl when L is -N (R4e) -, R4b and R4d and, together with a nitrogen atom and the carbon atoms to which R4b, R4c and R4d are respectively attached, form a pyrrolidine ring or a piperidine ring, each ring optionally substituted with one to six substituents independently selected from halo, C1-4 alkyl and C1-4 haloalkyl; or (b) R4b is selected from hydrogen and C1-4alkyl, R4d is hydrogen, L is -N (R4e) -, and R4c and R4e together with the carbon atoms and a nitrogen atom to which R4c, R4d and R4e are respectively attached, form a pyrrolidine ring or a piperidine ring, each ring optionally substituted with one to six substituents independently selected from halo, C1-4 alkyl and C1-4 haloalkyl; or (c) R4d is hydrogen, R 4e is selected from hydrogen and C1-4alkyl when L is -N (R4e) -, and 4b and R 4c together with the nitrogen and carbon atoms to which 4b and R 4c are respectively form a pyrrolidine ring or a piperidine ring, each ring optionally substituted with one to six substituents independently selected from halo, C1-4 alkyl and C1-4 haloalkyl; R5 is selected from hydrogen, halo and C1-4alkyl; each R6 is independently selected from -OR8, -N (R8) R9, -NR 8 C (O) R9, -NHC (O) NR8R9, - NR 8 C (O) NHR 9, -C (O) R8, -C (O) OR8 , -C (O) N (R8) R9, -C (O) N (R8) OR9, -C (O) N (R8) S (O) 2R7, -N (R8) S (O) 2R7, - SR8, -S (O) R7, -S (O) 2R7 and -S (O) 2N (R8) R9; each R7 is independently selected from (a) C1-6 alkyl, C2-6 alkenyl and C2-6 alkynyl, each optionally substituted with one to five substituents independently selected from halo, oxo, -CN and R10; and (b) C3-10- cycloalkyl (CH2) m-, aryl C6-14- (CH2) m-, C 2-6 heterocyclyl (CH2) m- and C1-9- heteroaryl (CH2) m-, each optionally substituted with one to five substituents independently selected from halo, oxo, -CN, R10 and C1-6 alkyl optionally substituted with one to five substituents independently selected from halo, oxo, -CN and R10; each R8 and R9 is independently selected from (a) hydrogen; (B) C1-6 alkyl, C2-6 alkenyl and C2-6 alkynyl, each optionally substituted with one to five substituents independently selected from halo, oxo, -CN and R10; and (c) C3-10- cycloalkyl (CH2) m-, aryl C6-14- (CH2) m-, C 2-6 heterocyclyl (CH2) m- and C1-9- heteroaryl (CH2) m-, each optionally substituted with one to five substituents independently selected from halo, oxo, -CN, R10 and C1-6 alkyl optionally substituted with one to five substituents independently selected from halo, oxo, -CN and R10; each R10 is independently selected from -OR11, -N (R11) R12, -N (R11) C (O) R12, -NHC (O) NR11R12, - NR 11 C (O) NHR12, -C (O) R11, -C (O) OR11, -C (O) N (R11) R12, -C (O) N (R11) OR12, -C (O) N (R11) S (O) 2R13, - NR11S (O) 2R13, - SR11, -S (O) R13, -S (O) 2R13 and -S (O) 2N (R11) R12; each R11 and R12 is independently selected from (a) hydrogen; and (b) C1-6alkyl and C3-10- cycloalkyl (CH2) m-, each optionally substituted with one to five substituents independently selected from halo, oxo, -CN, -OH and -NH2; each R13 is independently selected from C1-6 cycloalkyl and C3-10- (CH2) m- alkyl, each optionally substituted with one to five substituents independently selected from halo, oxo, - CN, -OH and -NH2; each R14 is independently selected from hydrogen, C1-4 alkyl and C1-4 haloalkyl; and each m is independently selected from 0, 1, 2, 3 and 4; wherein each heteroaryl and heterocyclyl R7, R8 and R9 independently has one to four heteroatoms, each heteroatom independently selected from N, O and S.