Roles of biochemical factors in lateral compartment wear from varus knee osteoarthritis

Objective To explore the roles of type Ⅱ collagen C-terminal telopeptide (CTX-Ⅱ), matrix metalloproteinase-13 (MMP-13) and interleukin-6 (IL-6) in lateral compartment wear in varus knee osteoarthritis. Methods Prospective reviews were conducted for the clinical data of varus knee osteoarthritis patients with lateral compartment wear undergoing total knee arthropalsty from June 2013 to June 2014.The gross findings of lateral compartment articular cartilage were recorded intraoperatively.And the slices were evaluated histologically.Synovial fluid was obtained by arthrocentesis.An equal number of operative patients from varus knee osteoarthritis without lateral compartment wear during the same period were selected and matched with respects to age, varus, preoperative range of motion and radiological grade of knee arthrosis.Synovial fluid concentrations of CTX-Ⅱ, MMP-13 and IL-6 were evaluated. Results Histologic examination showed microscopic cartilage degeneration in both groups.The concentrations of CTX-Ⅱ, IL-6 and MMP-13 in synovial fluid from lateral compartment wear group were (111.8±55.7) ng/L, (2.5±1.0) ng/L and (134.4±33.1) μg/L respectively.And there were no differences with control group (91.7±57.1) ng/L, (2.1±0.5) ng/L, (122.7±28.3) μg/L respectively. Conclusion The above biochemical factors may not play key roles in lateral compartment wear of varus knee osteoarthritis. Key words: Osteoarthritis, knee; Cartilage, articular; Genu varum