Acetylsalicylic acid does not prevent first‐trimester unexplained recurrent pregnancy loss: A randomized controlled trial

INTRODUCTION: Recurrent pregnancy loss occurs in about 1% of fertile couples. Without proper evidence for an effect, different treatments have been used when no etiological factor has been detected. The present trial is the first randomized trial to compare 75 mg acetylsalicylic acid with placebo for women with recurrent pregnancy loss. MATERIAL AND METHODS: This randomized, double-blind, placebo-controlled trial was conducted at a single center between 2008 and 2015. Recurrent pregnancy loss was defined as at least 3 consecutive first-trimester miscarriages within the couple. Women  80% with or without acetylsalicylic acid.