Research progress of Clostridium difficile-associated diarrhea

Clostridium difficile is a gram-positive, obligate anaerobic bacillus, which is one of the most common pathogenic bacteria of antibiotic associated diarrhea, and can cause Clostridium difficile-associated diarrhea.In recent years, the incidence of Clostridium difficile infection has increased significantly in the world with the excessive use of broad-spectrum antibiotics, the increase of strains resistance, and the emergence of hypervirulent strains.This paper presents a brief review on research progress of Clostridium difficile-associated diarrhea. Key words: Clostridium difficile; Toxin; Diarrhea; Infection; Child