B p65/RelA Subunit κ Phosphorylation and Activation of the NF- in Response to Interleukin-1 Leads to Activation of Phosphatidylinositol 3-Kinase

B), but the underlying mechanism remains to be de-termined. We have found that IL-1 stimulates interaction of the IL-1 receptor accessory protein with the p85regulatory subunit of PI3K, leading to the activation of the p110 catalytic subunit. Specific PI3K inhibitorsstrongly inhibit both PI3K activation and NF-