Determination of 5-aminosalicylic acid and related compounds in raw materials and pharmaceutical dosage forms by high-performance liquid chromatography
1991
Abstract A high-performance liquid chromatographic method using a μBondapak C 18 column and a UV detector at 230 nm was developed for the simultaneous determination of 5-aminosalicylic acid (5-ASA) and related compounds (4-aminophenol, 3-aminosalicylic acid and 3-aminobenzoic acid). A method for the determination of 5-ASA in pharmaceutical preparations (tablets, granules and rectal suspension) is also described. Calibration graphs for both 5-ASA and related compounds are reported. The standard deviation is ± 0.623 ( n = 10).
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