IDDF2019-ABS-0150 Therapeutic effect of fully covered self-expandable metal stents on benign biliary stricture

Background To evaluate the efficacy and safety of fully covered self-expandable metal stents (FCSEMSs) implanted by endoscopic retrograde cholangiopancreatography (ERCP) for patients with biliary stricture (BBS). Methods The clinical data of 38 patients with BBS underwent ERCP and FCSEMSs placement between January 2012 and January 2016 was retrospectively recorded. The success rate of BBS, adverse events related to ERCP and stricture recurrence were analyzed. Results A total of 38 patients underwent FCSEMSs placement with a mean time of stent indwell 8 months (3–13 months). During follow-up after the stent was removed, 1 patient after liver transplantation death was the unrelated cause. The mean follow-up time was 13 months (2–52 months) for other patients. Stricture recurrence occurred in 6 patients, including 2 cases of liver transplantation-related biliary strictures, 1 case of chronic pancreatitis-related biliary stricture. Stricture resolution occurred in 31 cases with 83.8% (31/37) success rate, including 90.0% (18/20) gallstone-related biliary stricture, 75.0% (3/4) chronic pancreatitis-related biliary stricture, 80.0%(8/10) liver transplantation-related biliary stricture, and 66.7% (2/3) post surgical-related biliary stricture. The incidence of post-ERCP complications was 21.1%(8/38), including mild pancreatitis in 5 cases, hyperamylasemia in 2 cases, cholangitis in 1 case. All patients were cured by conservative treatment. Conclusions FCSEMSs are effective and safe for BBS. Further studies are needed to assess the indwelling time of FCSEMSs, whether FCSEMSs are superior to multiple plastic stents and the different efficacy of FCSEMSs for BBS caused by different etiology.